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Scheme used to assign weights to each variant according to the predicted effect. (In the analyses described in this report, INDEL variants were not in fact used.)
| Predicted effect | Weight |
|---|---|
| NULL_CONSEQUENCE | 1 |
| INTERGENIC | 1 |
| DOWNSTREAM | 1 |
| INTRONIC | 3 |
| 3PRIME_UTR | 5 |
| SYNONYMOUS_CODING | 3 |
| UPSTREAM | 5 |
| 5PRIME_UTR | 5 |
| SPLICE_SITE | 5 |
| STOP_LOST | 5 |
| NON_SYNONYMOUS_CODING | 10 |
| CODINGINDEL | 15 |
| FRAMESHIFT_CODING | 20 |
| STOP_GAINED | 20 |
