Table 1.
Multivariate analysis of the OS and EFS in the Netherlands acute myeloid leukaemia series using Cox Regression analysis of those variables which were significant at the level of P < 0.1 in univariate Cox Regression
| Variable | OS | EFS | ||||||
|---|---|---|---|---|---|---|---|---|
| P‐value | HR | 95% CI for HR | P‐value | HR | 95% CI for HR | |||
| Lower | Upper | Lower | Upper | |||||
| S17 signature | <0·001 | 1·852 | 1·387 | 2·473 | <0·001 | 1·934 | 1·465 | 2·555 |
| Age | 0·026 | 1·121 | 1·013 | 1·239 | NS | ‐ | ‐ | ‐ |
| Complex karyotype | 0·001 | 2·198 | 1·397 | 3·458 | 0·001 | 2·182 | 1·354 | 3·518 |
| del(5q)/del(7q) | 0·017 | 1·76 | 1·109 | 2·795 | 0·001 | 2·027 | 1·322 | 3·109 |
| inv(16) | 0·027 | 0·537 | 0·31 | 0·931 | 0·036 | 0·569 | 0·336 | 0·964 |
| t(8;21) | 0·010 | 0·465 | 0·259 | 0·833 | 0·004 | 0·444 | 0·254 | 0·775 |
| FLT3‐ITD | 0·004 | 1·526 | 1·142 | 2·037 | 0·003 | 1·548 | 1·161 | 2·062 |
| NPM1‐mutated | 0·001 | 0·615 | 0·456 | 0·83 | 0·001 | 0·603 | 0·452 | 0·804 |
| CEBPA‐double‐mutated | 0·008 | 0·397 | 0·201 | 0·785 | 0·008 | 0·4 | 0·203 | 0·789 |
OS, overall survival; EFS, event‐free survival; HR, Hazard ratio.