Table 2.

Multivariate analysis of the OS and RFS in the Germany AML series using Cox Regression analysis of the ELN genetic groups and those variables which were significant at the level of P < 0·1 in univariate Cox Regression

Variable	OS				RFS
	P‐value	HR	95% CI for HR		P‐value	HR	95% CI for HR
			Lower	Upper			Lower	Upper
S17 signature	<0·001	1·485	1·186	1·860	<0·001	1·834	1·326	2·536
Age	<0·001	1·291	1·197	1·391	<0·001	1·198	1·081	1·327
ELN2a	<0·001	2·395	1·743	3·291	<0·001	3·147	2·124	4·663
ELN3a	<0·001	2·395	1·732	3·312	<0·001	2·153	1·405	3·299
ELN4a	<0·001	3·306	2·376	4·599	<0·001	6·401	4·027	10·175

OS, overall survival; RFS, relapse‐free survival; HR, Hazard ratio.

^aThe ELN2, ELN3, and ELN4 indicate the corresponding genetic ELN groups compared to the ELN1 group, respectively.