Table S5.
Haplotype analysis of VPS4A: Haplotype phases for VPS4A and their associations with node 1 (the striatum) and hyperactivity in the IMAGEN
| Haplotype | Frequency | rs246129 | rs153050 | rs16958736 | rs1127231 | rs3852689 | rs12258 | Striatal node | Hyperactivity in boys |
| Hap1 | 0.0699 | G | C | C | G | G | A | 6.30 × 10−2 | |
| Hap2 | 0.0490 | G | C | T | G | T | G | 1.38 × 10−3* | |
| Hap3 | 0.191 | G | C | C | G | T | G | 3.16 × 10−1 | |
| Hap4 | 0.0326 | G | C | T | A | G | G | 1.33 × 10−5‡ | 2.16 × 10−2† |
| Hap5 | 0.287 | A | T | C | A | G | G | 9.11 × 10−1 | |
| Hap6 | 0.0563 | G | T | C | A | G | G | 4.73 × 10−1 | |
| Hap7 | 0.0291 | A | C | C | A | G | G | 9.11 × 10−1 | |
| Hap8 | 0.272 | G | C | C | A | G | G | 2.39 × 10−1 | |
| Omnibus | 1.64 × 10−04‡ |
The frequency of each haplotype is provided. A, T, G, and C indicate nucleic acid adenine, thymine, guanine, and cytosine, respectively. An omnibus test (F test) was conducted to measure the overall influence of VPS4A haplotypes on the activation in node 1 (i.e., the comparison of models with/without the contribution of all haplotypes). The most significant haplotype phase (i.e., Hap4) with node 1 was then tested for association with hyperactivity in boys, where the hyperactivity and node 1 were observed in significant association.
Significance at level 0.01.
Significance at level 0.05.
Significance at level 0.001.