Table S1.

Pearson correlation coefficient (ρ) of the TH and IRI activity parameters determined from the sonocrystallization (sono, $T{H}_{nano}/\sqrt{C}$), nanoliter cryoscopy (cryo, $T{H}_{sono}/\sqrt{C}$), and IRI (C_i) experiments

Experiment	ρ	P value
Sono – cryo	0.30	0.57
Sono – IRI	−0.19	0.76
Cryo – IRI	−0.54	0.35

A perfect positive correlation between the activity parameters would be denoted by ρ = +1, and a perfect negative correlation by ρ = –1. Values of −0.5 < ρ < 0.5 represent no significant or weak correlation. P values > 0.05 represent no statistical significance.