Table 3. Electrocardiogram Analysis of Mice.
| Group | PR (ms) | QRS (ms) | QT (ms) |
|---|---|---|---|
| Control | 24 ± 1 | 11 ± 0.4 | 44 ± 1 |
| T4 | 24 ± 1 | 11 ± 1 | 42 ± 1 |
| DMSO + T4 | 23 ± 2 | 10 ± 1 | 42 ± 2 |
| Sorafenib + T4 | 24 ± 1 | 11 ± 1 | 42 ± 1 |
| TadalafilIP + T4 | 23 ± 1 | 12 ± 0.4 | 42 ± 1 |
| TadalafilOr + T4 | 21 ± 1 | 10 ± 1 | 41 ± 1 |
| CMC + T4 | 24 ± 1 | 10 ± 1 | 42 ± 1 |
| MacitentanLD + T4 | 23 ± 1 | 10 ± 1 | 43 ± 2 |
| MacitentanHD + T4 | 21 ± 2 | 11 ± 1 | 43 ± 2 |
ms: millisecond, Control; n = 7, Thyroxin (T4); n = 12, Dimethyl sulfoxide (DMSO); N = 6, Sorafenib; n = 9, TadalafilIP (intraperitoneal, 1 mg/kg); n = 7, TadalafilOr (oral, 4 mg/kg); n = 8, carboxymethylcellulose (CMC); n = 10, MacitentanLD (Low dose: 30 mg/kg); n = 9, MacitentanHD (High dose: 100 mg/kg); n = 7.