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. 2016 Apr 15;11(4):e0153828. doi: 10.1371/journal.pone.0153828

Table 4. Risk for offspring chronic musculoskeletal pain associated with the combined effect of parental chronic musculoskeletal pain and offspring body mass index.

Offspring activity-interfering CMP
Variables Normal weight Overweight Obese
No CMP
Cases/non-cases 67/399 57/265 11/57
Age-adjusted RR 1.00 1.30 1.15
RRa 1.00 (Ref.) 1.24 (0.91, 1.70) 1.12 (0.63, 1.98)
Any CMP, one parent
Case/non-case 282/928 282/928 87/254
Age-adjusted RR 1.36 1.66 1.75
RRa 1.34 (1.04, 1.71) 1.57 (1.23, 2.02) 1.60 (1.19, 2.15)
Any CMP, both parents
Case/non-case 113/454 113/349 41/71
Age-adjusted RR 1.37 1.78 2.57
RRa 1.32 (1.00, 1.74) 1.67 (1.27, 2.20) 2.33 (1.68, 3.24)

CMP: chronic musculoskeletal pain, CI: confidence interval, RR: relative risk.

aAdjusted for offspring factors in HUNT2; age (continuous), sex, leisure time physical activity (inactive, low, moderate, high, or unknown), physical work demands (mostly sedentary, much walking, much walking and lifting, heavy physical work, or unknown), psychological well-being (satisfied, somewhat satisfied, dissatisfied, or unknown), and education (<10 years, 10–12 years, ≥13 years, or unknown).