Table 3. Static-cidal (SC), Rate-of-kill (RoK) and CYP51 results for control compounds and selected hits from the bio-actives screen.
| Compound | MAX PI (SC)1 | pMCC (RoK) | CYP51 pIC50 |
|---|---|---|---|
| Nifurtimox | 103 | 5.3 | < 5 |
| Benznidazole | 91 | 4.8 | < 5 |
| Posaconazole | 59 | 7.0 | 7.5 |
| Ketoconazole | 61 | 8.1 | 7.9 |
| Clotrimazole | 60 | 7.6 | 7.4 |
| Bifonazole | 69 | 7.2 | 7.4 |
| Itraconazole | 71 | 7.2 | 7.5 |
| Econazole | 63 | 7.2 | 7.6 |
| Voriconazole | 70 | 7.2 | 7.4 |
| Clemastine | 108 | 6.7 | < 5 |
| Azelastine | 106 | 5.7 | < 5 |
| Amlodipine | 113 | 5.7 | < 5 |
| Ifenprodil | 117 | 5.7 | < 5 |
| Ziprasidone | 111 | 5.3 | < 5 |
| Clofibrate | 116 | 4.8 | < 5 |
| Abiraterone | 60 | 4.3 | <6 |
| Nilotinib | 38 | N/A | 6.8 |
1 Maximum Percent Inhibition in the static cidal assay, only derived from compound concentrations that are not toxic to the host cells.