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. 2016 Apr 15;14(4):e1002442. doi: 10.1371/journal.pbio.1002442

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© 2016 Callahan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — (A) MmeI (red) bound to DNA (yellow) superimposed on apo BpuSI (cyan). The helicase connector, methyltransferase, and DNA target recognition domain (TRD) labels correspond to both structures, while the endonuclease domain is only visible in the BpuSI structure. A comparison of the two structures reveals an ~38° rotation in the TRD, which clamps down on the DNA to make specific contacts. The TRD as a whole shifts by ~27 Å between the two structures. (B) A 90° rotation of the view in (a) to show the relative position of the endonuclease domain.