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. 2016 Apr 15;11(4):e0153632. doi: 10.1371/journal.pone.0153632

Fig 1. Expression of calcium handling and contractile proteins in 9 mo WT and Pkd2+/- mice.

Fig 1

(A) PC2 expression in the left ventricle was diminished by ~70% in Pkd2+/- mice compared with WT mice. (B) Expression of the intracellular calcium release channel RyR2 was increased, whereas SERCA2A and the phosphorylated form of PLB were decreased. NCX levels were unchanged. Data are quantified on the right. RyR2, SERCA2A and NCX are all normalized to tubulin. (C) The expression of the phosphorylated form of TnI was significantly increased in the Pkd2+/- mice. The levels of TnI and cTnT in the Pkd2+/- mice were diminished overall compared to the WT mice. Data are quantified on the right. Each lane represents a separate animal. *p < 0.05, **p < 0.01, ****p<0.0001.