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. 2016 Apr 8;11:1461–1473. doi: 10.2147/IJN.S101955

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© 2016 Kesireddy. This work is published and licensed by Dove Medical Press Limited

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TEMR–ADSC construct-repaired LD muscles display structural and functional hallmarks reminiscent of native muscles.

Notes: LD muscles repaired with TEMR–ADSC constructs were retrieved 2 months postimplantation and analyzed for morphology and new tissue formation by IHC staining on paraffin-embedded histological sections. IHC staining demonstrated positivity for structural proteins, myosin heavy chain (MF20; A) and titin (9D10; B). Similarly IHC staining revealed the presence of functional proteins, Junctophilin (Jp1; C) and ryanodine receptor 1 (RyR1; D).

Abbreviations: TEMR, tissue-engineered muscle repair; ADSC, adipose-derived stem cell; LD, latissimus dorsi; IHC, immunohistochemistry.