Table 1.
Ratio of different variables in the formulation and optimization of drug-loaded elastic liposomes
| Formulation | Variables
|
||||||
|---|---|---|---|---|---|---|---|
| Drug (mg) | SPC (% w/w) |
Hydration (15 mL) |
Span 80 (% w/w) |
SDC (% w/w) |
Tween 80 (% w/w) |
C:M (2:1) mL |
|
| F1 | 100 | 85 | 7% ethanol | 15 | – | – | 20:10 |
| F2 | 100 | 95 | 7% ethanol | 5 | – | – | 20:10 |
| F3 | 100 | 85 | 7% ethanol | – | 15 | – | 20:10 |
| F4 | 100 | 95 | 7% ethanol | – | 5 | – | 20:10 |
| F5 | 100 | 85 | 7% ethanol | – | – | 15 | 20:10 |
| F6 | 100 | 95 | 7% ethanol | – | – | 5 | 20:10 |
| F7 | 100 | 85 | PBS pH 6.4 | 15 | – | – | 20:10 |
| F8 | 100 | 95 | PBS pH 6.4 | 5 | – | – | 20:10 |
| F9 | 100 | 85 | PBS pH 6.4 | – | 15 | – | 20:10 |
| F10 | 100 | 95 | PBS pH 6.4 | – | 5 | – | 20:10 |
| F11 | 100 | 85 | PBS pH 6.4 | – | – | 15 | 20:10 |
| F12 | 100 | 95 | PBS pH 6.4 | – | – | 5 | 20:10 |
Abbreviations: SPC, soya phosphatidylcholine; SDC, sodium deoxycholate; C:M, chloroform:methanol; PBS, phosphate buffered saline.