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. 2016 Apr 15;11(4):e0153841. doi: 10.1371/journal.pone.0153841

Fig 2. Identification of the c.1111C>G (p.Gly371Arg) mutation in the OTOF gene and the c.2168A>G (p.His723Arg) mutation in the SLC26A4 gene in Altaian families.

Fig 2

(A) Extended pedigree of the WES family F54 (together with related family F24) with mutation c.1111C>G (p.Gly371Arg) in the OTOF gene denoted as M. (B) Validation of c.1111C>G by Sanger sequencing. (C) Pedigree of the WES family F53 with mutation c.2168A>G (p.His723Arg) in the SLC26A4 gene which is denoted as M. (D) Validation of c.2168A>G by Sanger sequencing. WES was performed for affected subjects indicated by blue codes. Black symbols represent individuals with congenital profound HL; grey symbol represents individual 24-II-1 with moderate or severe HL. wt—wild type.