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. 2016 Apr 15;11(4):e0153968. doi: 10.1371/journal.pone.0153968

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© 2016 Bianchi et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — A representative diagram characterizing the possible pathways by which ghrelin modulates the inflammatory response. Ghrelin binding to the GHSR receptor negatively modulates TGF-βR2, TGF-β3, TNF and IL13RA2 and up-regulates the inhibitory proteins SMAD7 and SMAD6, establishing the inhibition of TGF-β/Smads and p38-MAPK signaling pathways. This diagram was designed loading the fold change of ghrelin-treated samples versus controls into the Ingenuity pathway analysis software. Red highlighted genes represent overexpression and green represents underexpression of the factors of these pathways after ghrelin administration.