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(E) *Significant increase of the mean central hepatic vein diameter in the nicotine group compared with the saline group (p < 0.05). **Significant decrease in all groups of curcumin administration compared with the nicotine group (p < 0.05). ***Significant decrease in all groups of curcumin-nicotine administration compared with the nicotine group (p < 0.05). (A) Saline group. (B) Nicotine group. (C) Curcumin 60 mg/kg. (D) Curcumin (60 mg/kg) plus nicotine (magnification 100×).
