Table 3.
Gene | Location* | Marker | Allele | Allele frequency | Transmissions† | Non-transmissions | χ2 | P value |
---|---|---|---|---|---|---|---|---|
KCNJ5 | Intron 1 | rs11221503 | C | 0.813 | 60 | 69 | 0.628 | 0.428 |
T | 0.187 | 69 | 60 | |||||
Intron 1 | rs2604212 | C | 0.546 | 96 | 100 | 0.082 | 0.775 | |
G | 0.454 | 100 | 96 | |||||
Exon 2 (syn) | rs7118824 | G | 0.812 | 72 | 51 | 3.603 | 0.058 | |
T | 0.188 | 51 | 72 | |||||
Exon 2 (nonsyn) | rs7102584 | G | 0.018 | 5 | 9 | 1.159 | 0.282 | |
C | 0.982 | 9 | 5 | |||||
Intron 2 | rs11221512 | A | 0.095 | 24 | 38 | 3.189 | 0.074 | |
G | 0.905 | 38 | 24 | |||||
3′ | rs2604201 | A | 0.275 | 67 | 97 | 5.519 | 0.019 | |
G | 0.725 | 97 | 67 |
Based on NCBI Build 36.1, the March 2006 UCSC human reference sequence.
Number of times the alleles were transmitted from heterozygous parents to affected offspring in this sample.
P-values shown are not corrected for multiple testing. Experiment-wide significance threshold required to keep Type I error rate at 5%: 0.009.