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. Author manuscript; available in PMC: 2016 Apr 15.
Published in final edited form as: Genes Brain Behav. 2007 May 14;7(1):53–60. doi: 10.1111/j.1601-183X.2007.00325.x

Figure 1. Schematic representation of the CHRNA4 gene and association results reported for ADHD.

Figure 1

Lower panel shows the structure of the CHRNA4 gene. The six exons of the gene are represented by boxes, with black boxes for coding sequences and empty boxes for untranslated regions. Association findings are shown in the top panel with positive (+) and negative (−) results for the different studies. Of note, the Todd et al. findings presented here are not corrected for multiple tests and only rs6090384 remains significant after correction in that study. Markers involved in haplotypes showing evidence of association are shaded. Haplotypes from this study and Todd et al. were under-transmitted. The haplotype reported by Brookes et al. has a very low frequency (17 transmissions). Twelve other single nucleotide polymorphisms (SNPs), from intron 2 to 3′ untranslated region, have been tested by Brookes et al. (not shown here) and were all negative.