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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: ACS Chem Biol. 2016 Jan 6;11(4):889–899. doi: 10.1021/acschembio.5b00960

Figure 4. PaFS N-terminal GGPP cyclase domain.

Figure 4

(a) Stereoview of the PaFS344-Mg2+3-pamidronate complex reveals that the N-terminal domain adopts the α fold of a class I terpenoid synthase. (b) Stereoview of the PaFS344-Mg2+3-pamidronate complex showing metal coordination and hydrogen bond interactions as black and red dashed lines, respectively (metal-ligand distances are recorded in Supplementary Information Table S3). (c) The G60-F65 hairpin segment may facilitate communication between cyclization domain active sites in full-length hexameric PaFS by mediating interactions between active site residue F65 and interdomain linker residues N333 and Q336 (green).