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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Pancreas. 2016 May-Jun;45(5):659–670. doi: 10.1097/MPA.0000000000000522

Figure 3.

Figure 3

(A, B) Effect of inhibition of PTHrP signaling on the TGF-β-mediated increase in IL-6 and ICAM-1 mRNA levels in acinar cells. Cells were pre-treated with 10−5 M PTHrP (7-34) for 1 h, then treated in the presence of PTHrP (7-34) with TGF-β (3 ng/ml) for 2 h. 10 = primary cells. (C,D) Effect of TGF-β on IL-6 and ICAM-1 mRNA levels in PTHrPΔacinar cells and PTHrP+/+ acinar cells. IL-6 and ICAM-1 mRNA levels were measured by reverse transcription/real-time PCR. Values are expressed relative to the control value (A, B) or the respective 0 time value (C,D), set arbitrarily at 1.0. Each bar or point is the mean ± SEM of three independent experiments. ***, P < 0.001 vs. control (A,B) or 0 time-point (C,D); #, P < 0.01 vs. TGF-β alone (A,B) or PTHrP+/+ value (C,D).