Table 3. VGLUT1-IR contact densities on Renshaw cells.
| P15 | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| Animal Model |
Changes in VGLUT1 |
VGLUT1- IR contacts per 10 μm of dendrite (Average ± SEM) |
Percent change compared to wildtype |
P value (*, significant) t-test |
Total # of VGLUT1-IR contacts per cell (Average ± SEM) |
N (# animals, # Renshaw cells) |
|
| ||||||
| Wild-Type | 1.35 ± 0.15 | 26.72 ± 0.68 | 5, 57 | |||
| Er81 (−/−) | No VGLUT1 |
N/A | N/A | N/A | N/A | 3, 31 |
| Egr3 (−/−) | ↓ | 0.96 ± 0.16 | 30% ↓ | *p<0.001 | 21.08 ± 0.75 | 3, 37 |
| mlcNT3 (+/−) | ↑ | 1.76 ± 0.21 | 30% ↑ | *p<0.001 | 39.83 ± 0.99 | 3, 40 |
|
| ||||||
| P20 | ||||||
|
| ||||||
| Wild-Type | 0.96 ± 0.13 | 18.28 ± 0.57 | 5, 57 | |||
| Er81 (−/−) | No VGLUT1 |
N/A | N/A | N/A | N/A | 3, 37 |
| Egr3 (−/−) | ↓ | 0.83 ± 0.16 | 14% ↓ | *p<0.009 | 16.81 ± 0.72 | 3, 34 |
| mlcNT3 (+/−) | ↑ | 1.99 ± 0.24 | 107% ↑ | *p<0.001 | 35.89 ± 1.01 | 3, 35 |
|
| ||||||
| Adult | ||||||
|
| ||||||
| Wild-Type | 0.98 ± 0.15 | 20.18 ± 0.68 | 4, 44 | |||
| Er81 (−/−) | N/A | N/A | N/A | N/A | N/A | N/A |
| Egr3 (−/−) | ↓ | 0.70 ± 0.15 | 29% ↓ | *p<0.001 | 14.35 ± 0.68 | 3, 31 |
| mlcNT3 (+/−) | ↑ | 1.97 ± 0.24 | 101% ↑ | *p<0.001 | 37.24 ± 1.06 | 3, 33 |