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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Hypertension. 2016 Mar 28;67(5):970–976. doi: 10.1161/HYPERTENSIONAHA.115.06736

Figure 3.

Figure 3

Augmented pressor effects induced by Ang II during the expression (E) period in rats after pretreatment with HFD during the induction (I) period (Fig. 3A). This effect was attenuated by central (ICV) blockade of leptin receptors. Figure 3B shows the changes in MAP after infusion of Ang II during E in all groups. I-NFD = pretreatment with normal fat diet during I; I-HFD = pretreatment with high fat diet during I; ICV V = central treatment with vehicle during I; I-HFD+ICV SHLA = pretreatment with HFD plus central treatment with leptin receptor antagonist during I; E-Ang II = peripheral treatment with a pressor dose of Ang II during E. (* p<0.05 vs baseline or after diet treatment; # p<0.05 vs I-NFD+ICV V + E-Ang II and I-HFD+ICV SHLA+ E-Ang II)