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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Genet Epidemiol. 2016 Apr 6;40(4):284–292. doi: 10.1002/gepi.21963

Figure 3.

Figure 3

Power comparisons for ten models (two approaches of five meta-analytic methods) for the African-Specific Effects and Effect-size Heterogeneity scenarios for unequal vs. equal sample sizes (EAF=10% and α=1e-4). For equal sample size simulation, the sample size=3,000 for each study and 30,000 in total. For unequal sample size simulation, the sample size in the AfA studies is increased by 1.5 times (4,500) and the sample sizes in the other ancestry studies are decreased by 2/3 (2,000) but the total sample size (30,000) remains the same. (A) African-Specific Effects scenario using unequal sample size; (B) African-Specific Effects scenario using equal sample size; (C) Effect-size Heterogeneity scenario using unequal sample size; (D) Effect-size Heterogeneity scenario using equal sample size.