Anti-allergic ketotifen and budesonide reduce atherosclerotic lesion pathologies in Apoe−/− mice. A. Experimental protocol. Aortic arch atherosclerotic lesion area (B), lesion Mac-2-positive macrophage numbers, total and adventitia CD4+ T cells, total CD8+ T cells, and mast cells (C), media SMC loss grade (D), Ki67+ proliferating cells (E), lesion CD31+ microvessel numbers (F), and TUNEL-positive apoptotic cell numbers (G). Representative data in panels D and F are shown to the right. Scale: 200 μm.