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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Hypertension. 2016 Mar 14;67(5):977–982. doi: 10.1161/HYPERTENSIONAHA.115.06837

Table 3.

Association of Plasma Renin Activity with Serum Osteocalcin and Bone Mineral Density in African Ancestry Families

Bone Measure Model Difference (%) in bone measure per 1 SD PRA* P-value
Total Osteocalcin
(ug/l)		 Unadjusted −6.27 <0.0001
Base† −6.90 <0.0001
Multivariable‡ −8.26 <0.0001
Whole Body BMD
(g/cm2)		 Unadjusted −0.15   0.803
Base† 0.25   0.617
Multivariable‡ 0.51   0.301
Total Hip BMD
(g/cm2)		 Unadjusted 0.59   0.462
Base† 1.19   0.067
Multivariable‡ 1.19   0.070
Cortical BMD
(g/cm3)		 Unadjusted −0.11   0.445
Base† −0.17   0.195
Multivariable‡ −0.14   0.244
Trabecular BMD
(g/cm3)		 Unadjusted 1.78   0.020
Base† 1.94   0.003
Multivariable‡ 1.61   0.012
*

Values shown are the percent difference in bone measure per 1 SD (4.5 ng/mL/h) greater plasma renin activity.

†

Base model includes adjustment for age, sex, height and weight.

‡

Multivariable model includes adjustment for age, sex, height, weight, menopausal status, systolic blood pressure, diastolic blood pressure, hypertensive medication, eGFR, diabetes, current smoking, drinking, walking and calcium supplementation.