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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Hypertension. 2016 Mar 14;67(5):977–982. doi: 10.1161/HYPERTENSIONAHA.115.06837

Table 4.

Multivariable* Adjusted Genetic Correlations of Plasma Renin Activity with Osteocalcin and Bone Mineral Density

Bone Measure Heritability Plasma Renin Activity (H2r ± SE = 0.515 ± 0.10)
(H2r ± SE) ρG ρG P-value
Total OC (ug/l) 0.727 ± 0.11 −0.230 0.148
Whole Body BMD (g/cm2) 0.623 ± 0.12 −0.394 0.023
Total Hip BMD (g/cm2) 0.696 ± 0.10 −0.051 0.755
Cortical BMD (g/cm3) 0.444 ± 0.12 −0.266 0.148
Trabecular BMD (g/cm3) 0.622 ± 0.11 −0.266 0.139
*

Multivariable models include adjustment for age, sex, height, weight, menopausal status, systolic blood pressure, diastolic blood pressure, hypertensive medication, eGFR, diabetes, current smoking, drinking, walking and calcium supplementation.

H2r: residual genetic heritability estimate after adjustment; ρG estimated genetic bivariate correlation.