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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Cancer Cytopathol. 2015 Nov 30;124(4):261–272. doi: 10.1002/cncy.21661

Table 1.

Pooled sensitivity and specificity of HC2 to detect CIN2+ and CIN3+, and pooled disease rate in women diagnosed with ASC-H on cytology.

Outcome Nb of studies Sensitivity,% Specificity,% Disease rate, %
Pooled estimate (95% CI) Range Pooled estimate (95% CI) Range Pooled estimate (95% CI) Range
CIN2+ 19 93 (89–95) 68–100 45 (41–50) 26–72 34(28–40) 13–66
CIN3+ 5 91(81–96) 71–100 42 (34–51) 32–65 20(14–28) 11–36

Abbreviations: CIN2+, grade two cervical intraepithelial neoplasia or worse; CIN3+, grade three CIN or worse. HC2, Hybrid Capture-2 assay.