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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Biomaterials. 2016 Mar 21;92:71–80. doi: 10.1016/j.biomaterials.2016.03.028

Figure 4.

Figure 4

Pharmacokinetics and biodistribution of IV-injected FA-NPs. (A) FA-NPs have 1.1 h circulation half-life after i.v. administration via tail vein. (B) FA-NPs biodistribute to liver, kidney, and lungs after i.v. administration, but FA is cleared from these organs by 4 h post-injection. (C) FA imaging at 4 h after injection with FA-NPs reveals a significant increase in tumor signal relative to liver, kidney, or lungs. (n = 9, p < 0.004) (D) FA-NP signal is significantly higher in the inflamed footpad of mice over 8 h post-injection (n = 3, p < 0.01, *).