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. 2016 Mar 11;59(7):3183–3203. doi: 10.1021/acs.jmedchem.5b01963

Figure 1.

Figure 1

Plot showing lipophilicity (i.e., logD7.4), acidity (i.e., pKa), and permeability (i.e., logPapp) of test compounds, relative to the carboxylic acid compound 1; logD7.4 and logPapp values for compounds 1, 16, 14, and 17 are the averages obtained from three independent experiments; (**) p < 0.01 by two-tailed t test confirming statistical significant difference in membrane permeability between 16 and 1; NS indicates that the difference in logD7.4 values between 16 and 1 does not reach statistical significance.