TABLE 4. Comparison of clinical features in Possible MSA-C vs. Probable MSA-C.
The clinical features are compared at (A) intake visit and (B) cumulative visit, as in Table 3, in Possible and Probable MSA-C patients whose diagnosis was not confirmed pathologically.
| A Possible MSA-C vs Probable MSA-C: Intake Visit | |||
|---|---|---|---|
| Possible MSA-C |
Probable MSA-C |
Possible MSA-C v. Probable MSA-C p |
|
| Affected examined (n) | 10 | 43 | |
| Cerebellar signs | 10 (100) | 43 (100) | 1 |
| Gait ataxia | 10 (100) | 42 (98) | 1 |
| Lower extremity dysmetria | 9 (90) | 42 (98) | 0.34 |
| Upper extremity dysmetria | 9 (90) | 42 (98) | 0.34 |
| Dysarthria | 9 (90) | 41 (95) | 0.47 |
| Oculomotor | 9 (90) | 37 (86) | 1 |
| Handwriting affected | 9 (90) | 33 (77) | 0.67 |
| Requires Walker | 2 (20) | 16 (37) | 0.46 |
| Wheelchair bound | 0 (0) | 4 (9) | 1 |
| Extrapyramidal signs | 3 (30) | 16 (37) | 1 |
| Bradykinesia | 1 (10) | 7 (16) | 1 |
| Rigidity | 2 (20) | 8 (19) | 1 |
| Resting tremor | 0 (0) | 4 (9) | 1 |
| Corticospinal signs | 0 (0) | 15 (35) | 0.046 |
| Autonomic features | 5 (50) | 41 (95) | 0.002 |
| Systolic blood pressure drop of at least 30 mm Hg |
0/9 (0) | 16/41 (39) | 0.043 |
| Presyncopal symptoms | 1 (10) | 15 (35) | 0.25 |
| Urinary urgency or frequency | 5 (50) | 26 (60) | 0.72 |
| Urinary incontinence | 1 (10) | 14 (33) | 0.25 |
| Erectile dysfunction | 2/7 (29) | 24/25 (96) | < 0.001 |
| Other clinical signs and symptoms | 9 (90) | 41 (95) | 0.47 |
| Vertigo | 1 (10) | 3 (7) | 1 |
| Shortness of breath | 0 (0) | 3 (7) | 1 |
| Inspiratory stridor | 0 (0) | 1 (2) | 1 |
| Loud snoring | 1 (10) | 5 (12) | 1 |
| Dysphagia | 1 (10) | 15 (35) | 0.25 |
| REM sleep behavior disorder | 4 (40) | 19 (44) | 1 |
| Fatigue | 1 (10) | 5 (12) | 1 |
| Pathologic Laughing and Crying | 0 (0) | 5 (12) | 0.57 |
| Frontal Release Signs | 0 (0) | 5 (12) | 0.57 |
| Tinnitus | 1 (10) | 3 (7) | 1 |
| Mood | 3 (30) | 11 (26) | 1 |
| Constipation | 2 (20) | 6 (14) | 0.64 |
| Bowel Urgency / Incontinence | 0 (0) | 1 (2) | 1 |
| Cold Extremities | 1 (10) | 3 (7) | 1 |
| Sensory abnormalities | 0 (0) | 5 (12) | 0.57 |
| Absent ankle reflexes | 0 (0) | 1 (2) | 1 |
| Double vision | 1 (10) | 7 (16) | 1 |
| Dizziness (not presyncopal) | 4 (40) | 10 (23) | 0.43 |
| Cognitive Difficulties | 4 (40) | 18 (42) | 1 |
| B Possible MSA-C vs Probable MSA-C: Cumulative Visits | |||
|---|---|---|---|
| Possible MSA-C |
Probable MSA-C |
Possible MSA-C v. Probable MSA-C p |
|
| Affected examined (n) | 10 (100) | 43 (100) | |
| Cerebellar signs | 10 (100) | 43 (100) | 1 |
| Gait ataxia | 9 (90) | 43 (100) | 0.19 |
| Lower extremity dysmetria | 9 (90) | 43 (100) | 0.19 |
| Upper extremity dysmetria | 9 (90) | 43 (100) | 0.19 |
| Dysarthria | 9 (90) | 42 (98) | 0.34 |
| Oculomotor | 9 (90) | 42 (98) | 0.34 |
| Handwriting affected | 9 (90) | 36 (84) | 1 |
| Requires Walker | 4 (40) | 35 (81) | 0.014 |
| Wheelchair bound | 0 (0) | 18 (42) | 0.011 |
| Extrapyramidal signs | 5 (50) | 32 (74) | 0.15 |
| Bradykinesia | 1 (10) | 16 (37) | 0.14 |
| Rigidity | 5 (50) | 19 (44) | 1 |
| Resting tremor | 1 (10) | 16 (37) | 0.14 |
| Corticospinal signs | 1 (10) | 21 (49) | 0.034 |
| Autonomic features | 8 (80) | 43 (100) | 0.033 |
| Systolic blood pressure drop of at least 30 mm Hg |
0 (0) | 34 (79) | 0.0001 |
| Presyncopal symptoms | 4 (40) | 25 (58) | 0.48 |
| Urinary urgency or frequency | 8 (80) | 36 (84) | 1 |
| Urinary incontinence | 4 (40) | 31 (72) | 0.07 |
| Erectile dysfunction | 3/7 (43) | 24/25 (96) | 0.004 |
| Other clinical signs and symptoms | 9 (90) | 43 (100) | 0.19 |
| Vertigo | 2 (20) | 3 (7) | 0.23 |
| Shortness of breath | 0 (0) | 8 (19) | 0.33 |
| Inspiratory stridor | 0 (0) | 4 (9) | 1 |
| Loud snoring | 1 (10) | 12 (28) | 0.42 |
| Dysphagia | 3 (30) | 25 (58) | 0.16 |
| REM sleep behavior disorder | 5 (50) | 26 (60) | 0.72 |
| Fatigue | 1 (10) | 10 (23) | 0.67 |
| Pathologic Laughing and Crying | 0 (0) | 13 (30) | 0.10 |
| Frontal Release Signs | 0 (0) | 11 (26) | 0.10 |
| Tinnitus | 1 (10) | 4 (9) | 1 |
| Mood | 4 (40) | 23 (53) | 0.48 |
| Constipation | 2 (20) | 15 (35) | 0.47 |
| Bowel Urgency / Incontinence | 1 (10) | 8 (19) | 1 |
| Cold Extremities | 1 (10) | 9 (21) | 0.67 |
| Sensory abnormalities | 0 (0) | 7 (16) | 0.32 |
| Absent ankle reflexes | 0 (0) | 2 (5) | 1 |
| Double vision | 1 (10) | 17 (40) | 0.14 |
| Dizziness (not presyncopal) | 6 (60) | 18 (42) | 0.48 |
| Cognitive Difficulties | 4 (40) | 22 (51) | 0.73 |
| Imaging | |||
| Cerebellar Atrophy | 4/4 (100) | 22/23 (96) | 1 |
| Cerebellar Peduncle Atrophy | 1/4 (25) | 10/23 (43) | 0.62 |
| Brainstem Atrophy | 4/4 (100) | 17/23 (74) | 0.55 |