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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Mucosal Immunol. 2015 Oct 14;9(3):744–756. doi: 10.1038/mi.2015.98

Figure 4. LRRC31 correlation with esophageal eosinophilia and disease-associated gene expression.

Figure 4

a, Normalized LRRC31 mRNA expression in esophageal biopsies of patients with untreated, fluticasone propionate (FP)–treated, or diet therapy–treated EoE (14 normal controls [NL], 18 active eosinophilic esophagitis [EoE], 24 EoE treatment responders [R], 12 EoE treatment non-responders [NR]) by microarray gene expression analysis. b, Correlation of biopsy eosinophil count per high-power field (hpf) and normalized LRRC31 mRNA expression in esophageal biopsies of patients with active EoE determined by microarray gene expression analysis. Dotted line represents 15 eosinophils/hpf, the diagnostic threshold for EoE. Correlation of normalized LRRC31 mRNA expression with normalized IL13 (c), CCL26 (d), and IL5 (e) mRNA expression in esophageal biopsies of patients with active EoE determined by qPCR analysis. For a, data points represent individual subjects and data are represented as the mean ± SEM. NS, not significant; *P < 0.05, **P < 0.01, ***P < 0.001.