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. 2016 Apr 12;110(7):1476–1484. doi: 10.1016/j.bpj.2016.02.027

Figure 3.

Figure 3

Observed displacement MFPTs. Molecule number was counted as a function of time and fitted to a single rate, and MFPT was calculated as the reciprocal of that rate. We plot the average and standard deviation of observed MFPT against the mismatch position in both the invader and incumbent. The perfect match case is plotted in red without an x-label. The strands designed to be free of secondary structure are plotted in blue triangles. (a) Invader mismatch. The MFPT generally increases with mismatch position and shows a nearly 70-fold variation overall. Notably, at positions 7, 8, and 9, the MFPTs are higher than the overall trend. The MFPTs for strands without secondary structure align closely with their counterparts for the match strand and mismatch position 1 strand, but there is a clear distinction for the mismatch position 7 strands. (b) Incumbent mismatch. In comparison to (a) the mismatch position does not have a significant effect on the MFPT. To see this figure in color, go online.