Table 3.
Least-squares mean of IOP changes and percent IOP changes from baseline
| Time | 4 w | 8 w | 12 w | Pooled | ||
|---|---|---|---|---|---|---|
| 9 AM | 9 AM | 9 AM | 1 PM | 5 PM | 9 AM | |
| n | 30 | 30 | 30 | 30 | 30 | |
| ΔIOP (mmHg) | −3.2 | −3.3 | −3.6 | −3.1 | −2.9 | −3.4 |
| P value* | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| 95% CI | −3.8 to −2.6 | −4.0 to −2.7 | −4.2 to −3.0 | −3.7 to −2.5 | −3.5 to −2.3 | −3.9 to −2.9 |
| %ΔIOP (%) | −19.2 | −20.0 | −21.6 | −19.2 | −17.9 | −20.3 |
| P value* | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| 95% CI | −22.8 to −15.6 | −23.7 to −16.4 | −25.0 to −18.2 | −22.6 to −15.8 | −21.3 to −14.5 | −23.3 to 17.3 |
| IOP (mmHg) | 13.4 | 13.2 | 13.0 | 12.7 | 12.8 | 13.2 |
| 95% CI | 12.7 to 14.0 | 12.5 to 13.9 | 12.3 to 13.6 | 12.0 to 13.3 | 12.2 to 13.4 | 12.6 to 13.8 |
ΔIOP IOP change, CI confidence interval, IOP intraocular pressure, ΔIOP IOP change, %ΔIOP IOP percent change, n number, w week
* t test