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. 2016 Mar 16;17:17–31. doi: 10.1007/s10969-016-9202-4

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 12 — Intercalators that necessitate the transient rupture of hydrogen-bonds connecting base-pairs to gain entrance into (and exit out of) DNA (i.e., meso-tetra [4-N-methyl (pyridyl) porphine]) constitute convincing evidence that DNA-breathing and drug-intercalation are related phenomena [46]