Table 2.

The selected cirrhosis proteins and their correspond gene ontology information

	Uniprot ID: P02647
Molecular Function	Steroid binding, sterol binding, lipoprotein(receptor) binding, lipid binding, cholesterol binging,(lipid, sterol, cholesterol ) transporter activity
Cellular Component	Extracellular region, endoplasmic reticulum(lumen),plasma membrane, organelle lumen, extracellular region part, intera cellular organelle lumen
Biological Process	Regulation of protein amino acid phosphorylation,  immune response , cholesterol , steroid and lipid, metabolic process , cell motion, G-protein coupled receptor protein signaling pathway,  regulation of hormone levels,  very-low-density lipoprotein remodeling,, cellular amino derivative metabolic process, cholesterol homeostasis, positive regulation of catalytic activity,  regulation of system process, cell motility, chemical homeostasis, regulation of cytokine secretion , protein stabilization,  negative regulation of cellular component organization,  trans membrane transport, lipid homeostasis, sterol homeostasis, regulation of cellular localization, macromolecular complex assembly
	Uniprot ID: 06727
Molecular Function	Transporter activity for lipid, sterol and cholesterol, lipid binding, ion binding, cation binding, amine binding, alcohol binding, metal ion binding
Cellular Component	extracellular region, extracellular space, endoplasmic reticulum lumen, membrane-enclosed lumen, protein-lipid complex, plasma lipoprotein particle, very-low-density lipoprotein particle, high-density lipoprotein particle, chylomicron, , extracellular region part,  intracellular organelle lumen
Biological Process	Cellular response to oxidative stress, cellular amino derivative metabolic process, regulation of system process, metabolic process, immune response, cell adhesion, leukocyte adhesion, cell – cell adhesion, regulation of cholesterol absorption, regulation of lipid catabolic process, regulation of molecular function and assembly subunits, regulation off fatty acid biosynthetic process, chemical hemostasis, catabolic process, lipid hemostasis, sterol hemostasis
	Uniprot ID: P33622
Molecular Function	Llipid binding
Cellular Component	extracellular region, extracellular space, protein-lipid complex, plasma lipoprotein particle, very-low-density lipoprotein particle, triglyceride-rich lipoprotein particle, chylomicron
Biological Process	lipoprotein trygriceride mobilization, lipid transport, lipid localization, catabolic process of lipid , glycerol , acyl glycerol and triglyceride
	Uniprot ID: P51911
Molecular Function	Actin binding, calmodulin binding, cytoskeleton protein binding
Cellular Component	Cytoskeleton
Biological Process	cytoskeleton organization, actin filament-based process, actin cytoskeleton organization, actomyosin structure organization, regulation of system process
	Uniprot ID: P10643
Molecular Function	Actin binding, calmodulin binding, cytoskeleton protein binding
Cellular Component	Extra cellular region, membrane attack complex, plasma membrane
Biological Process	lymphocyte mediated immunity,  acute inflammatory response , proteolysis, cellular ion homeostasis  complement activation, ,cell death, B cell mediated immunity, cellular homeostasis, cytolysis, cellular , homeostatic process1, chemical homeostasis,  ion homeostasis, protein maturation, metal ion homeostasis, sodium ion homeostasis,  cellular chemical homeostasis
	Uniprot ID: P22455
Molecular Function	Nucleotide binding, ATP binding, fibroblast growth factor binding, growth factor binding, protein kinase activity
Cellular Component	plasma membrane, integral to plasma membrane, integral to membrane, intrinsic to membrane, intrinsic to plasma membrane, plasma membrane part
Biological Process	Cell fate specification, cell surface receptor linked signal transduction, cell- cell signaling, phosphorylation, developmental induction, cell proliferation, respiratory system development
	Uniprot ID: Q08380
Molecular Function	scavenger receptor activity
Cellular Component	extracellular region, proteinaceous extracellular matrix, extracellular space, extracellular matrix, extracellular region part
Biological Process	defense response, cell adhesion, biological adhesion
	Uniprot ID: P56470
Molecular Function	sugar binding
Cellular Component	cytosol, plasma membrane
Biological Process	cell adhesion, biological adhesion
	Uniprot ID: P55083
Molecular Function	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Cellular Component	micro fibril, extracellular region,  extracellular matrix, fibril, extracellular matrix part
Biological Process	cell adhesion, biological adhesion
	Uniprot ID: P13674
Molecular Function	cellular amino derivative metabolic process, iron ion binding, oxidoreductase activity, vitamin binding, peptidyl-prolin 4 dioxygenase activity, ion binding, cation binding, metal ion binding, transition metal ion binding
Cellular Component	mitochondrion, endoplasmic reticulum, endoplasmic reticulum lumen, membrane-enclosed lumen, organelle lumen, endoplasmic reticulum part, intracellular organelle lumen,
Biological Process	cellular amino derivative metabolic process , peptidyl-proline modification , collagen organization,oxidation reduction, extracellular structure and matrix organization
	Uniprot ID: Q01995
Molecular Function	actin binding, cytoskeletal protein binding
Biological Process	muscle organ development
	Uniprot ID: P07951
Molecular Function	structural molecular activity, actin binding, cytoskeletal protein binding, structural constituent of muscle
Cellular Component	cytoskeleton, muscle thin filament tropomyosin, striated muscle thin filament, actin cytoskeleton, myofibril, sarcomere, (intracellular)non-membrane-bounded organelle
Biological Process	regulation of hydrolase activity, regulation of ATP activity
	Uniprot ID: P67936
Molecular Function	actin binding, cytoskeletal protein binding, structural molecular activity calcium ion binding, structural constituent of muscle , ion binding, cation binding, metal ion binding
Cellular Component	cytoskeleton, muscle thin filament tropomyosin, striated muscle thin filament, actin cytoskeleton, myofibril, sarcomere,  cytoskeletal part, contractile fiber part
Biological Process	cell motion