Table 2. Decrease in mean peak height (± SD), compared with control (untreated skin) of asymmetric (Asy) and symmetric (Sym) C-H stretching and C=O stretching absorbance of abdominal hydrated whole skin rat following treatment with different vehicles (mean ± SD, n = 3) .
vehicles | Asymmetric C-H stretching | Symmetric C-H stretching | C=O stretching of lipid ester | |||
Peak height | %D | Peak height | %D | Peak height | %D | |
Control | 4.877±0.0015 | - | 5.026+0.0026 | - | 4.999±0.0065 | - |
PG | 0.021±0.002 | 99.56±1.05 | 0.023+0.0041 | 99.54+1.547 | 0.013±0.002 | 99.73±1.41 |
Span 80 | 0 | 100 | 1.95+0.041 | 61.2±1.004 | 1.874±0. 018 | 62.5±1.015 |
Tween 80 | 2.129±0.066 | 56.34±1.84 | 2.115±0.055 | 57.91+1.804 | 1.872±0.025 | 62.55±1.215 |
Labrafac PG | 2.092 ±0.008 | 57.1 ±1.93 | 1.999±0.078 | 59.01±2.11 | 1.944±0.045 | 61.1±1.312 |
Transcutol P | 1.888±0.012 | 61.28±2.01 | 1.850±0.114 | 63.19±2.29 | 1.640±0.051 | 67.19±1.493 |
*%Decrease in peak height(%D) =( peak height from untreated whole skin - peak height from solvent treated whole skin)/ peak height from untreated whole skin x 100