Table 5. Effect of vehicles on the thermal properties of hydrated whole abdominal rat skin (mean ± SD, n = 3) .
Treatment | Transition temperature (°C) | Enthalpy (mj/mg) | ||
Tm 1 | Tm 2 | ΔH 1 | ΔH 2 | |
Hydrated control | 67.5±2.1 | 112±6.6 | 7.01±0.4 | 552.1±19.5 |
PG | 77.5±4.2 | 132±5.9 | 6.05±0.6 | 16.4± 2.2 |
Span 80 | 38±0.53 | 117±2.1 | 0.051±0.006 | 0.711±0.012 |
Tween 80 | deleted | deleted | 0 | 0 |
Labrafac PG | 44.6±0.63 | 120±2.6 | 0.103±0.075 | 2.573±1.25 |
Transcutol P | 68±2.12 | deleted | 8.925±2.658 | - |
Tm1 = mean transison temperature of lipids; SCTm2= mean transition temperature of irreversible denaturation of intracellularstratum corneum keratin; ΔH1 = transition enthalpy of lipid phase SCΔH2 = transition enthalpy of keratin phase SC