Table 2.
Correlation between PI3K Hotspot Mutations (by NGS) and Biomarker Distribution (by IHC)
| Marker | PI3K Wild No. (%) | PI3K Mutant No. (%) | P Value⁎ | |
|---|---|---|---|---|
| Nuclear LKB1 | Low | 6 (40%) | 3 (42.9%) | .89 |
| High | 9 (60%) | 4 (57.1%) | ||
| Cytopl. LKB1 | Low | 6 (40%) | 3 (42.9%) | .89 |
| High | 9 (60%) | 4 (57.1%) | ||
| Nuclear pAKT | Low | 7 (46.7%) | 1 (14.3%) | .10 |
| High | 8 (53.3%) | 6 (85.7%) | ||
| Cytopl. pAKT | Low | 4 (26.7%) | 5 (71.4%) | .04 |
| high | 11 (73.3%) | 2 (28.6%) | ||
| pS6RP | Low | 6 (37.5%) | 5 (71.4%) | .10 |
| High | 10 (62.5%) | 2 (28.6%) | ||
| P4E-BP1 | Low | 10 (62.5%) | 6 (85.7%) | .19 |
| High | 6 (37.5%) | 1 (14.3%) | ||
⁎
Correlations by Fisher's exact test.