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. 2016 Apr 16;16:48. doi: 10.1186/s12883-016-0568-5

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© Schmidt et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Immunohistochemistry of inflammatory and degenerative markers in skeletal muscle of IBM patients before and after treatment with alemtuzumab. No significant changes were observed for CD8, MHC-I, the proinflammatory chemokine CXCL-9 and the cytokine IL-1β. Similarly, the degeneration-associated molecules nitrotyrosine, β-amyloid, αB-crystallin and NCAM remained without major variation. Subgroups are differentially labeled as responders (red) and non-responders (blue)