Table 4.
Multivariate Cox Regression Analysis on Selected Clinical Variables in the NCI Data Set Based on Significance in Univariate Analysis (see Supplementary Table 2)
| Disease-Free Survival |
Overall Survival |
|||||||
|---|---|---|---|---|---|---|---|---|
| P Value | Hazard Ratio | 95% CI |
P Value | Hazard Ratio | 95% CI |
|||
| Lower | Upper | Lower | Upper | |||||
| Gender (female vs male) | .083 | .544 | .273 | 1.082 | ||||
| Size largest nodule (> 5 cm vs < 5 cm) | .715 | .900 | .513 | 1.580 | ||||
| Multinodular (no vs yes) | .145 | 1.785 | .819 | 3.888 | ||||
| Cirrhosis (yes vs no) | .060 | 3.941 | .945 | 16.434 | ||||
| BCLC | .000 | .000 | ||||||
| BCLC (A vs 0) | .045 | 2.381 | 1.021 | 5.552 | .035 | 4.648 | 1.113 | 19.403 |
| BCLC (B vs 0) | .002 | 4.564 | 1.749 | 11.915 | .002 | 14.850 | 2.597 | 84.908 |
| BCLC (C vs 0) | .000 | 6.744 | 2.640 | 17.224 | .000 | 23.956 | 4.850 | 118.331 |
| aFP (> 300 ng/ml vs < 300 ng/ml) | .410 | 1.228 | .754 | 2.001 | ||||
| GRS group | .007 | .024 | ||||||
| GRS II vs I | .002 | 2.458 | 1.380 | 4.377 | .025 | 2.315 | 1.112 | 4.820 |
| GRS III vs I | .033 | 1.810 | 1.048 | 3.127 | .086 | 1.848 | .916 | 3.730 |
| GRS IV vs I | .002 | 2.372 | 1.378 | 4.083 | .003 | 2.870 | 1.446 | 5.696 |
GRS groups: GRS I = low GRS in tumor and liver; GRS II = low GRS in tumor, high in liver; GRS III = high GRS in tumor, low in liver; GRS IV = high GRS in tumor and liver.