Table 1.
Clinical and physiological parameters related to PH in IPF patients
| Parameters | PH unlikely (n = 71) | PH possible (n = 20) | PH likely (n = 28) | P1* | P2† |
|---|---|---|---|---|---|
| Age (years) | 65.44 ± 9.25 | 66.10 ± 12.35 | 69.00 ± 9.65 | 0.275 | |
| Male/female | 60/11 | 16/4 | 25/3 | 0.670 | |
| Duration (months) | 12 (2, 48) | 24 (6, 45) | 24 (12, 36) | 0.479 | |
| Borg dyspnea score | 2.63 ± 1.67 | 4.08 ± 1.82 | 4.54 ± 1.71 | 0.001 | 0.001 |
| SaO2 (%) | 95.9 (93.7, 96.8) | 94.5 (88.85, 96.4) | 92.65 (89.05, 95.4) | 0.001 | 0.045 |
| OI (mmHg) | 332.9 ± 94.4 | 284.5 ± 122.9 | 230.5 ± 108.8 | 0.001 | 0.226 |
| FVC (L) | 2.45 ± 0.83 | 2.22 ± 0.70 | 2.16 ± 0.54 | 0.288 | |
| FVC % pred | 71.18 ± 21.97 | 71.98 ± 23.53 | 64.91 ± 14.01 | 0.443 | |
| FEV1 (L) | 2.02 ± 0.64 | 1.83 ± 0.43 | 1.79 ± 0.35 | 0.241 | |
| FEV1% pred | 76.31 ± 21.24 | 76.21 ± 22.26 | 69.23 ± 10.42 | 0.422 | |
| FEV1/FVC (%) | 83.51 ± 8.10 | 84.08 ± 6.87 | 83.82 ± 10.19 | 0.971 | |
| TLC (L) | 4.30 ± 1.14 | 3.92 ± 1.33 | 3.87 ± 1.01 | 0.293 | |
| TLC % pred | 71.28 ± 17.88 | 74.81 ± 30.15 | 62.93 ± 15.77 | 0.205 | |
| RV/TLC (%) | 42.68 ± 10.42 | 40.64 ± 15.06 | 43.01 ± 8.80 | 0.798 | |
| DLCO % pred | 36.87 ± 17.70 | 29.02 ± 15.34 | 21.67 ± 16.88 | 0.006 | 0.002 |
| DLCO-VA %pred | 60.67 ± 21.49 | 48.50 ± 19.67 | 43.12 ± 27.81 | 0.011 | 0.696 |
| Width of PA (mm) | 25.29 ± 2.89 | 27.59 ± 3.61 | 30.18 ± 5.87 | 0.001 | |
| NT-pro BNP‡ (pg/ml) | 260 (55, 510) | 766 (184, 2734) | 2049 (507, 4662) | 0.002 |
Data were presented as mean ± SD/medians and IQR or number (%) unless otherwise indicated. *P1 value was obtained by using different statistical method to compare the difference of clinical parameters among IPF patients with different sPAP; †P2 value was obtained using multiple linear regression; ‡Data on 53 patients were available. P<0.05 was considered to be statistically significant. PH: pulmonary hypertension; SaO2: Oxygen saturation; OI: Oxygen index; FVC: Forced vital capacity; FEV1: Forced expiratory volume in 1 s; TLC: Total lung capacity; RV: Residual volume; DLCO: Diffusing capacity of the lung for carbon monoxide; VA: Alveolar ventilation; PA: Pulmonary artery; NT-pro BNP: N-terminal fragment of pro-brain natriuretic peptide; SD: Standard deviation; IQR: Interquartile range; IPF: Idiopathic pulmonary fibrosis.