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. 2015 Apr 5;128(7):948–955. doi: 10.4103/0366-6999.154303

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Copyright: © 2015 Chinese Medical Journal

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Interferon gamma mediated hemorrhage is STAT1-independent. STAT1 KO mice and genetically matched 129S6 controls were injected with biotin and infected with 10 ME49 cysts of Toxoplasma gondii. On day 8 of infection, blood and fecal samples were collected and analyzed. (a) Hematocrit levels in 129S6 and STAT1^−/− mice were significantly decreased as compared with sham controls; (b) Reticulocyte numbers were not significantly different between Toxoplasma gondii infected and sham control mice; (c) Both 129S6 and STAT1^−/− mice lost a significant number of biotinylated red blood cell as a result of T. gondii infection. Significant differences are shown (*P < 0.05). All data are represented as mean ± SD of at least four mice per group.