Fig. 13.
Circular-view PACT system combined with reversely switchable BphP1 for deep imaging. (a) Contrast-to-noise ratio (CNR) of U87 cells imaged by PACT at 10-mm depth. (b) Whole-body mouse images acquired with BphP1 at different state. The differential image clearly shows that the tumor is at the left kidney. (c) An overlay of the differential image (in color) and the blood-dominated OFF-state image (in grayscale). (d) Normalized PA amplitude along the dashed line in (b), showing the contrast enhancement of the tumor in the differential image. (e) A histology image of the left kidney showing the tumor region. (f) PACT image of a mouse brain with a U87 tumor expressing BphP1. The tumor was beneath the scalp. Reproduced with permission from Ref. 121.