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. Author manuscript; available in PMC: 2016 Apr 29.
Published in final edited form as: Curr Drug Targets. 2010 Oct:1250–1261. doi: 10.2174/1389450111007011250

Figure 1. electrophysiological and muscle pathological features of LMN degeneration in skeletal muscle.

Figure 1

A. Electrophysiological (EMG) recording of a patient with ALS demonstrating fibrillation potentials at rest, i.e. spontaneous denervation-related muscle activity.

B–D. Muscle biopsy of a patient with ALS. All the features associated with neurogenic disorders, i.e. grouping of atrophic fibers (B,C), predominance of one type of fiber (D), and presence of angulated fibers (D), are observed.

(B: semi-thin section, X 250; C: H–E staining, X 200; D: NADH-TR staining, X 100).