Skip to main content
. Author manuscript; available in PMC: 2016 Apr 29.
Published in final edited form as: Curr Drug Targets. 2010 Oct:1250–1261. doi: 10.2174/1389450111007011250

Figure 3. potential mechanisms involving skeletal muscle in SBMA.

Figure 3

The mutant AR toxicity is unmasked by testosterone. This leads to myopathic features, such as myotonic discharges and elevation of blood CK, contributing to muscle weakness and letality. On the other hand, mutant AR toxicity (or wild type AR overexpression) dismantles NMJs through yet unknown mechanisms. A pathogenic function of mutant AR in motor neurons has also been documented. See text (section 4) for further details.