Figure 5.

Goodness‐of‐fit plots for the population pharmacokinetic model of bolus 5‐fluorouracil (5‐FU) in pediatric patients. The 5‐FU observed vs. population (a) and individual (b) predicted concentrations. Individually weighted residual vs. population predicted concentrations (c). (Open circle represents individual values; red dashed line represents the line of identity or a horizontal line at y = 0; purple dashed line represents local regression line (LOWESS)). Visual predictive check for pediatric patients receiving 400 (d), 500 (e), or 650 (f) mg/m² 5‐FU i.v. bolus. (Open circle represents observed individual plasma concentrations; solid line represents the median (50th percentile) of model predicted individual concentrations; dashed lines represent the 5th and 95th percentile of model predicted individual concentrations; the red horizontal dashed line is the lower limit of quantitation.)