Table 2.
Final pediatric population pharmacokinetic parameter estimates
| Parameters | Unit | Estimate ± SE | IIV (% CV) | IOV |
|---|---|---|---|---|
| Systemic clearance (CLp) | L/hr/m2 | 16.6 ± 1.2 | 28.8 | 13.0 |
| Volume of central compartment (V1,p) | L/m2 | 4.2 ± 0.3 | 26.6 | NE |
| Intercompartmental clearance (Qp) | L/hr/m2 | 1.6 ± 0.7 | 80.1 | NE |
| Volume of peripheral compartment (V2,p) | L/m2 | 20.1 ± 8.6 | 93.9 | NE |
| Residual variability | ||||
| Proportional | 0.51 ± 0.04 | |||
| Additive | 1.98 ± 1.5 |
CV, coefficient of variation; IIV, interindividual variability; IOV, interoccasion variability; NE, not estimated.