Table 3.
Time (min) necessary to release 10, 50, and 90% of the loaded drug.
| CAl 600 | CAl 400 | CAlCh 600 | CAlCh 400 | |
|---|---|---|---|---|
| HCl | ||||
| t10% | 24 | 12 | 31 | 85 |
| t50% | — | — | — | — |
| t90% | — | — | — | — |
|
| ||||
| pH 6.8 | ||||
| t10% | 16 | 19 | 10 | 30 |
| t50% | 130 | 110 | 261 | 310 |
| t90% | 290 | 220 | >8 h | >8 h |
|
| ||||
| pH 7.4 | ||||
| t10% | 16 | 25 | 28 | 35 |
| t50% | 229 | 187 | 423 | >8 h |
| t90% | >8 h | 444 | >8 h | >8 h |