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Aged mice suffer higher levels of pulmonary inflammation upon S. pneumoniae challenge. PMN recruitment (A) and cytokine levels (B) in the lungs of aged (black bars) and young (gray bars) mice were measured 48 h after intratracheal challenge with 106 CFU S. pneumoniae. Combined data from two separate experiments (n = 6 mice per group) are shown. ** p < 0.001 indicates means are significantly different by Mann–Whitney U test.
