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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Exp Neurol. 2016 Feb 15;279:13–26. doi: 10.1016/j.expneurol.2016.02.009

Figure 4. The effects of butyrate analogues and prodrugs on the body mass curves of SMNΔ7 SMA mice.

Figure 4

(A-D) Body mass curves of SMNΔ7 SMA mice (solid circles) or non-SMA littermates (either carrier or normal; open circles) treated daily with either BA (A), 4PBA (B), BA3G (C) or VX563 (D). Body mass curves for vehicle-treated SMNΔ7 SMA and non-SMA mice are shown as solid and open triangles, respectively. (E) Growth rates, which are defined by the change in body mass between PND14 and PND04, of SMNΔ7 SMA treated with either BA, 4PBA, BA3G, VX563 or their appropriate vehicle along with non-SMA littermates. The mean body masses at PND14 were expressed relative to those at PND04. The asterisk (*) denotes a statistically significant (p ≤ 0.05) difference when compared to vehicle-treated SMNΔ7 SMA mice for each drug.