Table 3.
Association between global DNA methylation levels classified by the tertiles of the distribution of controls and renal cell carcinoma risk
| 5-mC% | Cases n (%) | Controls n (%) | ORa | 95% CI | P value | ORb | 95% CI | P value |
|---|---|---|---|---|---|---|---|---|
| T3 | 247(27.78) | 296(33.30) | 1(Ref) | 1(Ref) | ||||
| T2 | 286(32.17) | 294(33.07) | 1.18 | (0.92–1.50) | 0.19 | 1.30 | (0.98–1.72) | 0.07 |
| T1 | 356(40.04) | 299(33.63) | 1.46 | (1.15–1.84) | 1.64E-03 | 1.40 | (1.06–1.84) | 0.02 |
| p for trend | 1.49E-03 | 0.02 |
5-mC%, 5-methylcytosine percentage
a
Conditional logistic regression model adjusting for gender, age and ethnicity
b
Conditional logistic regression model adjusting for gender, age, ethnicity, smoking status, BMI, hypertension, physical activity and family cancer history
T3, third tertile of methylation (≥5.25); T2, second tertile of methylation (3.1–5.24); T1, first tertile of methylation (≤3.1)